Malegra 100 mg is a widely used erectile dysfunction medication containing 100 mg of Sildenafil Citrate. Manufactured by Sunrise Remedies, it offers a reliable and affordable alternative to branded PDE5 inhibitors. With its well-balanced effectiveness and safety profile, Malegra 100 mg is suitable for men with mild to moderate erectile dysfunction. It supports improved erectile function during sexual stimulation through enhanced penile blood flow.

– **Active Ingredient**: Sildenafil Citrate – 100 mg per tablet
– **Type**: Film-coated, round tablet
– **Manufacturer**: Sunrise Remedies Pvt. Ltd.

Malegra 100 mg works by selectively inhibiting the PDE5 enzyme, which breaks down cGMP in the corpus cavernosum. During sexual arousal, nitric oxide (NO) triggers the release of cGMP, causing smooth muscle relaxation and increased blood flow to penile tissues. By blocking PDE5, Malegra prolongs the effects of cGMP, enabling stronger and more sustained erections. Importantly, sexual stimulation is required—it does not cause automatic erection.

– **Onset**: 30–60 minutes
– **Peak effects**: 60–90 minutes
– **Duration**: Up to 5–6 hours
– **Half-Life**: Approximately 4 hours
– Absorption may be delayed by high-fat meals

– **Recommended dose**: 50–100 mg based on doctor’s advice
– **Taken**: 30–60 minutes before sexual activity
– **Frequency**: Once every 24 hours
– **Note**: Should not be taken more than once daily. Start with 50 mg then increase only if well tolerated.

– Men with mild to moderate erectile dysfunction
– Those who did not get desired results from 50 mg dose
– Men seeking a cost-effective alternative to branded options
– Patients with controlled underlying health conditions

– Ensure no concurrent use of nitrates or nitric oxide donors
– Avoid in cases of recent heart attack, stroke, or severe heart disease
– Consult a doctor if you have liver or kidney problems
– Not recommended during third trimester of pregnancy (for female partners)
– Avoid if under 18 or over 65 without medical supervision

– **Common**: Headache, flushing, indigestion, nasal congestion, dizziness, visual disturbances
– **Less common**: Facial pain, back pain, nausea
– **Serious**: Priapism (erection >4 hours), sudden vision/hearing loss, chest pain — seek immediate medical attention if experienced

– Contraindicated: Nitrates, Riociguat
– Caution with: Alpha-blockers, blood pressure meds, CYP3A4 inhibitors (e.g., erythromycin, ketoconazole)
– Avoid grapefruit juice (may increase blood levels of sildenafil)

– **Absorption**: Oral bioavailability ~40%
– **Metabolism**: Liver via CYP3A4 (major) and CYP2C9 (minor)
– **Excretion**: ~80% via feces, ~13% in urine
– **Protein Binding**: ~96%

– Store at room temperature, away from heat and moisture
– Keep capsules in original container
– Dispose of expired or unused tablets responsibly